Other cross-reactions of the imidazolic drugs occur with the preservative isothiazolonone. Therefore, cross-reactions secondary to the topical application of imidazole-containing drugs can occur. At the time he consulted to the allergy clinics he had lesions with the same characteristics as described above that had appeared four days after starting treatment with oral ketoconazole, 200 mg/d, which was prescribed for tinea pedis ( Figures 1 and 2).Ĭontact dermatitis due to cross-reactions between tioconazole and other imidazoles, 6 and between ketoconazole and miconazole 7 have also been published. The patient referred that he had similar lesions at the same sites in multiple occasions every time he took self-prescribed metronidazole for non-specific gastrointestinal complaints such as abdominal pain and meteorism. The lesions were localised in the back, posterior surfaces of the thighs, dorsal aspect of the right hand, and lumbar region. 2 In the present paper we will discuss the case of a patient who developed FDE to cross-reacting drugs containing the imidazole ring.Ī 51-year-old male patient consulted because he noticed recurrent rounded erythematous and hyperpigmented plaques in the same anatomic areas for the last five years. 1,2 The drugs most commonly involved in FDE induction include phenolphthalein, sulphonamides, barbiturics, tetracyclins, aspirin and phenylbutazone. Together with the exanthemas, urticaria, angio-oedema and multiforme erythema, FDE are the most common allergic reactions to drugs, constituting about 10% of all drug reactions. Lesions are well delimited rounded or oval plaques, erythematous to violaceous with an erythematous border, pruriginous and painful, various centimetres in diameter, and which can evolve to vesicles and leave residual hyperpigmentation. Fixed drug eruptions (FDE) are defined as erythematous plaques recurring at the same anatomical localisation in every occasion that the drug is re-administered to the allergic patient. More than 10% of them are hypersensitivity reactions. See moreĪdverse drug reactions are a frequent cause of consultation in allergology and dermatology services that affect up to 10% of the population (20% in hospitalised patients). Letters to the Editor on previously published papers are welcomed.Allergologia et Immunopathologia publishes 6 issues per year and is included in the major databases such as Pubmed, Scopus, Web of Knowledge, etc. Occasionally, the opinion of an expert on a burning topic is published in the "Point of View" The journal accepts original and review articles from all over the world, together with consensus statements from the aforementioned societies. It has and independent international Editorial Committee which submits received papers for peer-reviewing by international experts. Allergologia et Immunopathologia is the official journal of the Spanish Society of Pediatric Allergy and Clinical Immunology. Manuscripts related to clinical, epidemiological and experimental allergology and childhood immunopathology will be considered for publication. Allergologia et Immunopathologia is no longer published on Elsevier since the 2021 year.Transferred to Codon PublicationsĪllergologia et Immunopathologia is a forum for those working in the field of asthma, allergy and immunology related to childhood.
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